故事发生在1896年的纽约，那时的纽约一片繁荣景象，一边是科技的长足进步，一边是贫富差距的加剧。这时发生了一连串男童妓被残忍杀害的事件，新任警察局长（日后的第26任美国总统）西奥多·罗斯福找来了犯罪心理学家拉兹洛·克莱斯勒、记者约翰·摩尔去秘密调查。他们并非孤军奋战，时任局长秘书（日后成为首位女警探）莎拉·霍华德组织了一个行动小组，利用心理学和新兴的法医学，抽丝剥茧，去抓捕这个连环杀手。
夜间新闻节目《新闻大门》的新闻编辑部迎来新人户山纱矢（佐佐木舞香 饰），她因祖母的喜好而误打误撞进入新闻行业。在节目改版的混乱中，遇见了志向成为记者却迷茫的入社两年目AD本桥悠介（道枝骏佑 饰），两人因一句话逐渐拉近距离，发展出“秘密关系”。与此同时，温柔体贴的同事宰善（金武俊 饰）也默默守护着纱矢。围绕三人展开的青春×梦想×悸动的职场爱情喜剧由此上演。
This 7-year series chronicled the adventures of the Impossible Mission Taskforce (IMF), a team of government spies and specialists who were assigned "impossible missions" by the unseen "Secretary". Although the cast varied over the years, the main characters included The Team Leader (Dan Briggs the first season, then Jim Phelps the other six), The Techno-Wizard (Barney Collier), The Strongman (Willy Armitage), The Master of Disguise (first Rollin Hand, then The Amazing Paris), and The Femme Fatale (Cinnamon Carter, Casey, Dana Lambert, Mimi Davis). The series is best known for its opening mission assignment (conducted by a pre-recorded tape), the theme composed by Lalo Schifrin, the leader's selection of mission agents from a dossier, the opening briefing, the intricate use of disguises and a typical "mask pulloff" scene near the end of most episodes, and the relative lack of characterization of the characters.
