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　　仁（松坂桃李 饰）和秀（菅田将晖 饰）出生于医生世家，他们的父亲是一位德高望重的医生，希望两个儿子长大后能够继承自己的事业。然而，叛逆桀骜的仁却并没有那份医者的仁心，热爱音乐的他组建了一支乐队，并且在演出中被音乐经纪人相中，他决定正式出道成为一名歌手。
　　仁的决定让他和父亲之间爆发出了激烈的争吵，最终，仁决绝的离开了家。在哥哥和父亲的关系降到冰点的那段日子里，温柔的秀正在艰苦的进行着备考，成绩不算优异的他最终选择了牙科大学作为奋斗的目标。仁的音乐道路走得十分不顺利，各种利益的冲突让他和队友们之间亦产生了隔阂。而顺利考入了大学的秀，在某日拿起哥哥的吉他之后忽然发现了音乐带给他的抚慰和力量。

　　The world of Remnant is filled with horrific monsters bent on the destruction of humanity. Fortunately, the kingdoms of the world have risen to combat these forces by training powerful Huntsmen and Huntresses at academies around the planet. Ruby Rose, Weiss Schnee, Blake Belladonna, and Yang Xiao Long are four such Huntresses in training whose journeys will take them far past the grounds of Beacon Academy. Though each may be powerful on their own, these four girls must come together to work as a team if they truly hope to become the next generation of Remnant's protectors. But can they succeed at each other's side when dark forces gather to divide and destroy humanity?